Deleterious variants in genes associated with bone mineral density are linked to susceptibility to periodontitis development

Studies have investigated the relationship between periodontitis and the decrement of the bone mineral density (BMD). However, there is limited knowledge on the possible association between BMD-related genes and susceptibility to periodontitis development. To fill this gap, a total of 157 genes, previously associated with BMD, were analyzed in 442 subjects affected by chronic periodontitis. Candidate gene analyses resulted in two RBMS3 deleterious variants, rs55872743 and rs7636555, significantly associated (p-value < 3.28 × 10−06) with periodontitis status. These results will shed new light on the possible role of genes linked to BMD affecting periodontitis.