Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy / da Silva, R.C., Alves, N.M.P., Pereira, J.J.S., Coelho, A.V.C., Arraes, L.C., Brandao, L.A.C., Crovella, S., Silva, J.A.. - In: GENETICS AND MOLECULAR BIOLOGY. - ISSN 1415-4757. - 42:2(2019), pp. 351-356. [10.1590/1678-4685-gmb-2017-0289]
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
Crovella S.;
2019-01-01
Abstract
Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.| File | Dimensione | Formato | |
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