Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy / da Silva, R. C.; Alves, N. M. P.; Pereira, J. J. S.; Coelho, A. V. C.; Arraes, L. C.; Brandao, L. A. C.; Crovella, S.; Silva, J. A.. - In: GENETICS AND MOLECULAR BIOLOGY. - ISSN 1415-4757. - 42:2(2019), pp. 351-356. [10.1590/1678-4685-gmb-2017-0289]
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
Crovella S.;
2019-01-01
Abstract
Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.| File | Dimensione | Formato | |
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