Gender distribution of COVID-19 severity is unbalanced. Higher mortality rates are reported in men (60-70% deaths in men). We reviewed 243 BCGitis cases reported in the literature. The M/F ratio in BCGitis is 49:1 and is not fully explained by the higher incidence of bladder cancer among males, neither by anatomical reasons. We discuss the M/F ratio in BCGitis in the light of immune system differences among different genders, with a focus on interferon response (higher in females).
Interferon: the invisible link between COVID-19 and BCGitis female protection?
Di Bella, Stefano;Cabas, Paolo
;Rizzo, Michele
2020-01-01
Abstract
Gender distribution of COVID-19 severity is unbalanced. Higher mortality rates are reported in men (60-70% deaths in men). We reviewed 243 BCGitis cases reported in the literature. The M/F ratio in BCGitis is 49:1 and is not fully explained by the higher incidence of bladder cancer among males, neither by anatomical reasons. We discuss the M/F ratio in BCGitis in the light of immune system differences among different genders, with a focus on interferon response (higher in females).File in questo prodotto:
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DI BELLA SJI 2020 Interferon invisible link BCG letter.pdf
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