Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation - is there enough evidence?: reply from the authors

We thank Hermasch et al. for their comments on our paper describing the novel NCSTN R583* mutation associated to familial acne inversa (FAI) in an Italian family, where the proband was also clinically diagnosed with Dowling-Degos disease (DDD). In our report, we raised the attention on this particular patient subset with comorbid FAI-DDD, emphasizing the connection between autoinflammatory-keratinization disorders and genetic reticulated pigmentary disorders. Based on our findings, we think that there ais enough evidence to claim that R583* NCSTN mutation is associated with DDD and FAI.