Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely accepted surrogate of overall genomic DNA methylation content, was found to be associated with a poor prognosis in several cancers. At present, no studies have investigated the influence of LINE-1 methylation levels on OPSCC relapse. The main goal of this study was the evaluation of the prognostic value of LINE-1 methylation status in predicting early tumor relapse in locally advanced OPSCC.
Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma / Furlan, C., Polesel, J., Barzan, L., Franchin, G., Sulfaro, S., Romeo, S., Colizzi, F.S., Rizzo, A., Baggio, V., Giacomarra, V., Dei Tos, A.P., Boscolo-rizzo, P., Vaccher, E., Dolcetti, R., Sigalotti, L., Fratta, E.. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - ELETTRONICO. - 9:1(2017), pp. 58."-"-58."-". [10.1186/s13148-017-0357-z]
Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma
Dei Tos, Angelo Paolo;Boscolo-rizzo, Paolo;
2017-01-01
Abstract
Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely accepted surrogate of overall genomic DNA methylation content, was found to be associated with a poor prognosis in several cancers. At present, no studies have investigated the influence of LINE-1 methylation levels on OPSCC relapse. The main goal of this study was the evaluation of the prognostic value of LINE-1 methylation status in predicting early tumor relapse in locally advanced OPSCC.| File | Dimensione | Formato | |
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