Attenzione: i dati modificati non sono ancora stati salvati. Per confermare inserimenti o cancellazioni di voci è necessario confermare con il tasto SALVA/INSERISCI in fondo alla pagina
ArTS Archivio della ricerca di Trieste
Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database / Vincent, J.-L., Ferguson, A., Pickkers, P., Jakob, S.M., Jaschinski, U., Almekhlafi, G.A., Leone, M., Mokhtari, M., Fontes, L.E., Bauer, P.R., Sakr, Y., Tomas, E., Bibonge, E.A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., et al.. - In: CRITICAL CARE. - ISSN 1364-8535. - 24:1(2020), pp. 171."-"-171."-". [10.1186/s13054-020-02858-x]
The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database
Vincent J. -L.
;Ferguson A.;Pickkers P.;Jakob S. M.;Jaschinski U.;Almekhlafi G. A.;Leone M.;Mokhtari M.;Fontes L. E.;Bauer P. R.;Sakr Y.;Tomas E.;Bibonge E. A.;Charra B.;Faroudy M.;Doedens L.;Farina Z.;Adler D.;Balkema C.;Kok A.;Alaya S.;Gharsallah H.;Muzha D.;Temelkov A.;Georgiev G.;Simeonov G.;Tsaryanski G.;Georgiev S.;Seliman A.;Vrankovic S.;Vucicevic Z.;Gornik I.;Barsic B.;Husedzinovic I.;Pavlik P.;Manak J.;Kieslichova E.;Turek R.;Fischer M.;Valkova R.;Dadak L.;Dostal P.;Malaska J.;Hajek R.;Zidkova A.;Lavicka P.;Starkopf J.;Kheladze Z.;Chkhaidze M.;Kaloiani V.;Medve L.;Sarkany A.;Kremer I.;Marjanek Z.;Tamasi P.;Krupnova I.;Vanags I.;Liguts V.;Pilvinis V.;Vosylius S.;Kekstas G.;Balciunas M.;Kolbusz J.;Kubler A.;Mielczarek B.;Mikaszewska-Sokolewicz M.;Kotfis K.;Tamowicz B.;Sulkowski W.;Smuszkiewicz P.;Pihowicz A.;Trejnowska E.;Hagau N.;Filipescu D.;Droc G.;Lupu M. N.;Nica A.;Stoica R.;Tomescu D. R.;Constantinescu D. L.;Valcoreanu Zbaganu G. M.;Slavcovici A.;Bagin V.;Belsky D.;Palyutin S.;Shlyapnikov S.;Bikkulova D.;Gritsan A.;Natalia G.;Makarenko E.;Kokhno V.;Tolkach A.;Kokarev E.;Belotserkovskiy B.;Zolotukhin K.;Kulabukhov V.;Soskic L.;Palibrk I.;Jankovic R.;Jovanovic B.;Pandurovic M.;Bumbasirevic V.;Uljarevic B.;Surbatovic M.;Ladjevic N.;Slobodianiuk G.;Sobona V.;Cikova A.;Gebhardtova A.;Jun C.;Yunbo S.;Dong J.;Feng S.;Duan M.;Xu Y.;Xue X.;Gao T.;Xing X. Z.;Zhao X.;Li C. H.;Gengxihua G.;Tan H.;Xu J.;Jiang L.;Tiehe Q.;Bingyu Q.;Shi Q.;Lv Z.;Zhang L.;Jingtao L.;Zhen Z.;Wang Z.;Wang T. H.;Yuhong L.;Zhai Q.;Chen Y.;Wang C.;Jiang W.;Ruilan W.;Chen Y.;Xiaobo H.;Ge H.;Yan T.;Yuhui C.;Zhang J.;Jian-Hong F.;Zhu H.;Huo F.;Wang Y.;Li C.;Zhuang M.;Ma Z.;Sun J.;Liuqingyue L.;Yang M.;Meng J.;Ma S.;Kang Y.;Yu L.;Peng Q.;Wei Y.;Zhang W.;Sun R.;Yeung A.;Wan W. L.;Sin K. K. C.;Lee K. L.;Wijanti M.;Widodo U.;Samsirun H.;Sugiman T.;Wisudarti C.;Maskoen T. T.;Hata N.;Kobe Y.;Nishida O.;Miyazaki D.;Nunomiya S.;Uchino S.;Kitamura N.;Yamashita K.;Hashimoto S.;Fukushima H.;Adib N. A. N.;Tai L. L.;Tony B.;Bigornia R. R.;Bigornia R. R.;Palo J. E.;Chatterjee S.;Tan B. H.;Kong A.;Goh S.;Lee C. -C.;Pothirat C.;Khwannimit B.;Theerawit P.;Pornsuriyasak P.;Piriyapatsom A.;Mukhtar A.;Hamdy A. N.;Hosny H.;Ashraf A.;Mokhtari M.;Nowruzinia S.;Lotfi A. H.;Zand F.;Nikandish R.;Moghaddam O. M.;Cohen J.;Sold O.;Sfeir T.;Hasan A. Y.;Abugaber D.;Ahmad H.;Tantawy T.;Baharoom S.;Algethamy H.;Amr A.;Almekhlafi G.;Coskun R.;Sungur M.;Cosar A.;Gucyetmez B.;Demirkiran O.;Senturk E.;Ulusoy H.;Atalan H. K.;Serin S.;Kati I.;Alnassrawi Z.;Almemari A.;Krishnareddy K.;Kashef S.;Alsabbah A.;Poirier G.;Marshall J. C.;Herridge M.;Fernandez-Medero R.;Fulda G.;Banschbach S.;Quintero J.;Schroeder E.;Sicoutris C.;Gueret R.;Kashyap R.;Bauer P.;Nanchal R.;Wunderink R. G.;Jimenez E.;Ryan A.;Prince D.;Edington J.;Van Haren F.;Bersten A.;Hawkins D. J.;Kilminster M.;Sturgess D.;Ziegenfuss M.;O' Connor S.;Lipman J.;Campbell L.;McAllister R.;Roberts B.;Williams P.;Parke R.;Seigne P.;Freebairn R.;Nistor D.;Oxley C.;Young P.;Valentini R.;Wainsztein N.;Comignani P.;Casaretto M.;Sutton G.;Villegas P.;Galletti C.;Neira J.;Rovira D.;Hidalgo J.;Sandi F.;Caser E.;Thompson M. M.;D'Agostino Dias M.;Fontes L. E.;Lunardi M. C.;Youssef N. C.;Lobo S.;Silva R.;Sales J. A.;Melo L. M. C.;Oliveira M.;Fonte M.;Grion C.;Feijo C.;Rezende V.;Assuncao M.;Neves A. P.;Gusman P.;Dalcomune D.;Teixeira C.;Kaefer K.;Maia I.;Dantas V. S.;Filho R. C.;Amorim F.;Assef M.;Schiavetto P.;Houly J.;Bianchi F.;Dias F.;Avila C.;Rego L.;Castro P.;Passos J.;Mendes C.;Grion C.;Mecatti G. C.;Ferrreira M.;Irineu V.;Guerreiro M.;Ugarte S.;Tomicic V.;Godoy C.;Samaniego W.;Escamilla I.;Castro Castro L. F.;Duque G. L.;Diaz-Guio D.;Benitez F.;Urrego A. G.;Buitrago R.;Ortiz G.;Villalba Gaviria M. C.;Salas D.;Ramirez-Arce J.;Salgado E.;Morocho D.;Vergara J.;Sang M. C.;Orellana-Jimenez C.;Garrido L.;Diaz O.;Resiere D.;Osorio C.;De La Vega A.;Carrillo R.;Sanchez V.;Villagomez A.;Zubieta R. M.;Sandia M.;Zalatiel M.;Poblano M.;Gonzalez D. R.;Arrazola F.;Juan Francisco L. L.;Namendys-Silva S. A.;Moya R. G.;Hernandez M.;Rodriguez Cadena D. M.;Islas I. L.;Ballesteros Zarzavilla C. M.;Matos A.;Oyanguren I.;Cerna J.;Sierra R. Q.;Jimenez R.;Castillo L.;Ocal R.;Sencan A.;Mareque Gianoni S. M.;Deicas A.;Hurtado J.;Burghi G.;Martinelli A.;Von Der Osten I.;Du Maine C.;Bhattacharyya M.;Bandyopadhyay S.;Yanamala S.;Gopal P.;Sahu S.;Ibrahim M.;Rathod D.;Mukundan N.;Dewan A.;Amin P.;Samavedam S.;Shah B.;Gurupal G.;Lahkar B.;Mandal A. K.;Sircar M.;Ghosh S.;Balasubramani V.;Kapadia F.;Vadi S.;Nair K.;Tripathy S.;Nandakumar S.;Sharma J.;Kar A.;Jha S.;Zirpe K.;Patel M.;Bhavsar A.;Samaddar D. P.;Kulkarni A.;Hashmi M.;Ali W.;Nadeem S.;Indraratna K.;Margarit A.;Urbanek P.;Schlieber J.;Reisinger J.;Auer J.;Hartjes A.;Lerche A.;Janous T.;Kink E.;Krahulec W.;Smolle K. -H.;Van Der Schueren M.;Thibo P.;Vanhoof M.;Ahmet I.;Gadisseux P.;Dufaye P.;Jacobs O.;Fraipont V.;Biston P.;Dive A.;Bouckaert Y.;Gilbert E.;Gressens B.;Pinck E.;Collin V.;Vincent J. -L.;De Waele J. J.;Rimachi R.;Gusu D.;De Decker K.;Mandianga K.;Heytens L.;Wittebole X.;Spapen H.;Van Collie O.;Vandenheede W.;Rogiers P.;Kolodzeike P.;Kruse M.;Andersen T.;Harjola V. -P.;Saarinen K.;Leone M.;Durocher A.;Moulront S.;Lepape A.;Losser M. -R.;Cabaret P.;Kalaitzis E.;Zogheib E.;Charve P.;Francois B.;Lefrant J. -Y.;Beilouny B.;Forceville X.;Misset B.;Jacobs F.;Floccard B.;Payen D.;Wynckel A.;Castelain V.;Faure A.;Lavagne P.;Lepoivre T.;Moussa M. D.;Vieillard-Baron A.;Durand M.;Gainnier M.;Ichai C.;Arens S.;Hoffmann C.;Kaffarnik M.;Scharnofske C. -J.;Voigt I.;Peckelsen C.;Weber M.;Gille J.;Lange A.;Schoser G.;Sablotzki A.;Jaschinski U.;Bluethgen A.;Vogel F.;Tscheu A.;Fuchs T.;Wattenberg M.;Helmes T.;Scieszka S.;Heintz M.;Sakka S.;Kohler J.;Fiedler F.;Danz M.;Sakr Y.;Riessen R.;Kerz T.;Kersten A.;Tacke F.;Marx G.;Volkert T.;Schmutz A.;Nierhaus A.;Kluge S.;Abel P.;Janosi R. A.;Utzolino S.;Bracht H.;Toussaint S.;Peftoulidou M. G.;Myrianthefs P.;Armaganidis A.;Routsi C.;Xini A.;Mouloudi E.;Kokoris I.;Kyriazopoulos G.;Vlachos S.;Lavrentieva A.;Partala P.;Nakos G.;Moller A.;Stefansson S. O.;Barry J.;O'Leary R. A.;Motherway C.;Faheem M.;Dunne E.;Donnelly M.;Konrad T.;Bonora E.;Achilli C.;Rossi S.;Castiglione G.;Peris A.;Albanese D.;Stocchetti N.;Citerio G.;Mozzoni L.;Sisillo E.;De Negri P.;Savioli M.;Vecchiarelli P.;Puflea F.;Stankovic V.;Minoja G.;Montibeller S.;Calligaro P.;Sorrentino R.;Feri M.;Zambon M.;Colombaroli E.;Giarratano A.;Pellis T.;Capra C.;Antonelli M.;Gullo A.;Chelazzi C.;De Capraris A.;Patroniti N.;Girardis M.;Franchi F.;Berlot G.;Buttigieg M.;Ponssen H.;Ten Cate J.;Bormans L.;Husada S.;Buise M.;Van Der Hoven B.;Reidinga A.;Kuiper M.;Pickkers P.;Kluge G.;Den Boer S.;Kesecioglu J.;Van Leeuwen H.;Flaatten H.;Mo S.;Branco V.;Rua F.;Lafuente E.;Sousa M.;Catorze N.;Barros M.;Pereira L.;De Oliveira A. V.;Gomes J.;Gaspar I.;Pereira M. F.;Cymbron M.;Dias A.;Almeida E.;Beirao S.;Serra I.;Ribeiro R.;Povoa P.;Faria F.;Costa-E-Silva Z.;Nobrega J. J.;Fernandes F.;Gabriel J.;Voga G.;Rupnik E.;Kosec L.;Povsic M. K.;Osojnik I.;Tomic V.;Sinkovic A.;Gonzalez J.;Zavala E.;Valenzuela J. P.;Marina L.;Vidal-Cortes P.;Posada P.;Martin-Loeches I.;Guillen N. M.;Palomar M.;Sole-Violan J.;Torres A.;Gonzalez Gallego M. A.;Aguilar G.;Allue R. M.;Argueso M.;Parejo M.;Navarro M. P.;Jose A.;Nin N.;Lerma F. A.;Martinez O.;Lozano E. T.;Lopez S. A.;Perez Granda M. J.;Moreno S.;Llubia C.;Martos C. D. L. F.;Gonzalez-Arenas P.;Fernandez N. L.;Rueda B. G.;Pons I. E.;Cruza N.;Maroto F.;Estella A.;Ferrer A.;Fraile L. I.;Quindos B.;Quintano A.;Tebar M. T.;Cardinal P.;Reyes A.;Rodriguez A.;Abella A.;Del Valle S. G.;Yus S.;Maseda E.;Berezo J. A.;Pedregosa A. T.;Laplaza C.;Ferrer R.;Rico-Feijoo J.;Rodriguez M.;Monedero P.;Eriksson K.;Lind D.;Chabanel D.;Zender H.;Heer K.;Frankenberger B.;Jakob S.;Haller A.;Matthew S.;Downes R.;Groba C. B.;Johnston A.;Meacher R.;Keays R.;Haji-Michael P.;Tyler C.;Ferguson A.;Jones S.;Tyl D.;Ball A.;Vogel J.;Booth M.;Downie P.;Watters M.;Brett S.;Garfield M.;Everett L.;Heenen S.;Dhir S.;Beardow Z.;Mostert M.;Brosnan S.;Pinto N.;Harris S.;Summors A.;Norton A.;Rose A.;Appelboam R.;Davies O.;Vickers E.;Agarwal B.;Szakmany T.;Wimbush S.;Welters I.;Pearse R.;Hollands R.;Kirk-Bayley J.;Fletcher N.;Bray B.;Brealey D.;Alexander P.;Henderson S.;Hargreaves C.;Black H.;Gowda K.
2020-01-01
Abstract
Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2979075
Citazioni
18
26
22
social impact
Conferma cancellazione
Sei sicuro che questo prodotto debba essere cancellato?
simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
