Challenges in interpreting the diagnostic performance of symptoms to predict COVID-19 status: the case of anosmia

We performed a review of the literature to identify studies that tested patients with flulike symptoms for SARS‐CoV‐2 infection by RT‐PCR and that reported data on the prevalence of loss of smell and/or taste. We identified a total of 6 studies (Fig. 1A).2, 4, 7‐10 Sensitivity and specificity were represented using forest plots, and pooled estimates were calculated using a random intercept logistic regression model. Publication bias was assessed by funnel plot. PPVs and NPVs were calculated as a function of prevalence of COVID‐19, ranging from 0% to 100%, using pooled sensitivity and specificity.