Impact of mesoporous silica on the chemical degradation of Praziquantel upon grinding

Praziquantel and Syloid 244 FP (amorphous silicon dioxide) were ground in a vibrational mill in standard conditions (15 or 30 min at 25 Hz). Amorphous solid dispersions were obtained in a very short grinding time (15 min), as testified by DSC, PXRD and ESEM analyses. Samples ground at 15 min and 30 min showed the presence of the same degradation product, as was evident from UPLC, MS and NMR analyses. This short paper brings to light the tremendous lattice de-structuration ability of Syloid 244 FP upon grinding toward Praziquantel as well as its detrimental influence on promoting chemical degradation through ring opening and oxidation.