Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2- breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2- early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer / Griguolo, Gaia; Dieci, Maria Vittoria; Paré, Laia; Miglietta, Federica; Generali, Daniele; Frassoldati, Antonio; Cavanna, Luigi; Bisagni, Giancarlo; Piacentini, Federico; Tagliafico, Enrico; Cagossi, Katia; Ficarra, Guido; Prat, Aleix; Conte, Pierfranco; Guarneri, Valentina. - In: NPJ BREAST CANCER. - ISSN 2374-4677. - ELETTRONICO. - 7:1(2021), pp. 12."-"-12."-". [10.1038/s41523-021-00223-x]
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
Generali, Daniele;
2021-01-01
Abstract
Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2- breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2- early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.| File | Dimensione | Formato | |
|---|---|---|---|
|
griguolo g.pdf
accesso aperto
Tipologia:
Documento in Versione Editoriale
Licenza:
Creative commons
Dimensione
1.23 MB
Formato
Adobe PDF
|
1.23 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
