Meta-analyses have the advantage of providing a summary effect estimate when there are a number of methodologically homogenous studies that examine the same intervention in the same study populations. Fortyfive days after the publication of the Recovery trial, a meta-analysis of eight randomized trials (7,184 participants) was published, and a corresponding WHO guideline panel subsequently recommended systemic corticosteroids in patients with severe and critical COVID-19 (strong recommendation, based on moderate certainty evidence).
Caution When Comparing the Impact of Corticosteroids in COVID-19 / Confalonieri, Marco; Salton, Francesco; Confalonieri, Paola; Rochwerg, Bram; Meduri, Umberto G.. - In: CHEST. - ISSN 0012-3692. - STAMPA. - 160:2(2021), pp. e243-e244. [10.1016/j.chest.2021.04.026]
Caution When Comparing the Impact of Corticosteroids in COVID-19
Confalonieri, Marco
;Salton, Francesco;Confalonieri, Paola;
2021-01-01
Abstract
Meta-analyses have the advantage of providing a summary effect estimate when there are a number of methodologically homogenous studies that examine the same intervention in the same study populations. Fortyfive days after the publication of the Recovery trial, a meta-analysis of eight randomized trials (7,184 participants) was published, and a corresponding WHO guideline panel subsequently recommended systemic corticosteroids in patients with severe and critical COVID-19 (strong recommendation, based on moderate certainty evidence).| File | Dimensione | Formato | |
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Chest letter 2021.pdf
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