Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies.
Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19 / Shafiee, S., Cegolon, L., Khafaei, M., Gholami, N., Zhao, S., Khalesi, N., Moosavian, H., Fathi, S., Izadi, M., Ghadian, A., Javanbakht, M., Javanbakht, A., Akhavan-Sigari, R.. - In: CANCER CELL INTERNATIONAL. - ISSN 1475-2867. - 21:1(2021), pp. 431."-"-431."-". [10.1186/s12935-021-02129-x]
Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
Cegolon L.;
2021-01-01
Abstract
Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies.| File | Dimensione | Formato | |
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