PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone–rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 6 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 188 of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and—in 50% of the cases—fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.

Early Detection of Central Visual Function Decline in Cone-Rod Dystrophy by the Use of Macular Focal Cone Electroretinogram

MARANGONI D;
2013-01-01

Abstract

PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone–rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 6 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 188 of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and—in 50% of the cases—fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/3002586
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