Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid. (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.
Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies / Vianello, M; Tavolato, B; Armani, M; Giometto, B. - In: THE CEREBELLUM. - ISSN 1473-4222. - 2:1(2003), pp. 77-79. [10.1080/14734220309432]
Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies
Giometto B
2003-01-01
Abstract
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid. (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.Pubblicazioni consigliate
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