A contrast agent suitable for magnetic resonance imaging based on small, water soluble gold nanoparticles (AuNP) conjugated to over 50 Gd3+ chelators has been prepared by using an interfacial Michael addition in aqueous media. The resultant chelator-AuNP conjugates have been successfully characterised by H-1 NMR spectroscopy, IR spectroscopy, ICP-OES, delta-potential analysis, TEM and MRI. T-1-weighted in vivo images of mouse kidney were obtained using the agent at 9.4 T. A preliminary in vivo experiment produced no ill effects and the clearance profile of the agent suggests it is suitable for animal testing at clinically relevant concentrations.
Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(III) chelate via Michael addition for use as a MRI contrast agent / Milne, M; Gobbo, P; Mcvicar, N; Bartha, R; Workentin, Ms; Hudson, Rhe. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-750X. - 1:41(2013), pp. 5628-5635. [10.1039/c3tb20699h]
Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(III) chelate via Michael addition for use as a MRI contrast agent
Gobbo P;
2013-01-01
Abstract
A contrast agent suitable for magnetic resonance imaging based on small, water soluble gold nanoparticles (AuNP) conjugated to over 50 Gd3+ chelators has been prepared by using an interfacial Michael addition in aqueous media. The resultant chelator-AuNP conjugates have been successfully characterised by H-1 NMR spectroscopy, IR spectroscopy, ICP-OES, delta-potential analysis, TEM and MRI. T-1-weighted in vivo images of mouse kidney were obtained using the agent at 9.4 T. A preliminary in vivo experiment produced no ill effects and the clearance profile of the agent suggests it is suitable for animal testing at clinically relevant concentrations.Pubblicazioni consigliate
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