Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Patients with intermediate stage (Barcelona Clinic Liver Cancer, B stage) hepatocellular carcinoma (HCC) have been able to benefit from TACE (transarterial chemoembolization) as a treatment option. MicroRNAs (miRNAs), i.e., a subclass of non-coding RNAs (ncRNAs), participate in post-transcriptional gene regulation processes and miRNA dysfunction has been associated with apoptosis resistance, cellular proliferation, tumor genesis, and progression. Only a few studies have investigated the role of miRNAs as biomarkers predicting TACE treatment response in HCC. Here, we review the studies’ characteristics from a radiological point of view, also correlating data with radiological images chosen from the cases of our institution.

MicroRNAs Related to TACE Treatment Response: A Review of the Literature from a Radiological Point of View

Bozzato A. M.
;
Martingano P.;Cavallaro M. F. M.;Cesarotto M.;Marcello C.;Tiribelli C.;Pascut D.;Pizzolato R.;Croce L. S.;Cova M. A.
2022

Abstract

Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Patients with intermediate stage (Barcelona Clinic Liver Cancer, B stage) hepatocellular carcinoma (HCC) have been able to benefit from TACE (transarterial chemoembolization) as a treatment option. MicroRNAs (miRNAs), i.e., a subclass of non-coding RNAs (ncRNAs), participate in post-transcriptional gene regulation processes and miRNA dysfunction has been associated with apoptosis resistance, cellular proliferation, tumor genesis, and progression. Only a few studies have investigated the role of miRNAs as biomarkers predicting TACE treatment response in HCC. Here, we review the studies’ characteristics from a radiological point of view, also correlating data with radiological images chosen from the cases of our institution.
1-feb-2022
Pubblicato
https://www.mdpi.com/2075-4418/12/2/374
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871153/
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/3023051
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