Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to the conventional amphiphile. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, allowing effective and specific cellular uptake.  All these highlight their great promise for targeted delivery.

Bola-Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate-Binding Proteins

Laurini, Erik;Pricl, Sabrina;
2022

Abstract

Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to the conventional amphiphile. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, allowing effective and specific cellular uptake.  All these highlight their great promise for targeted delivery.
12-lug-2022
Pubblicato
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202201400
File in questo prodotto:
File Dimensione Formato  
Chemistry A European J - 2022 - Zhang - Bola‐Amphiphilic Glycodendrimers New Carbohydrate‐Mimicking Scaffolds to Target.pdf

accesso aperto

Tipologia: Documento in Versione Editoriale
Licenza: Creative commons
Dimensione 5.16 MB
Formato Adobe PDF
5.16 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/3027346
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact