The first catalytic asymmetric Wittig reaction is presented. Hydrogen-bond donors catalyze the [2+2] cycloaddition reaction between stabilized phosphorus ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.
Organocatalytic Asymmetric Wittig Reactions: Generation of Enantioenriched Axially Chiral Olefins Breaking a Symmetry Plane / Gramigna, Lucia; Duce, Sara; Filippini, Giacomo; Fochi, Mariafrancesca; Franchini, Mauro; Bernardi, Luca. - In: SYNLETT. - ISSN 0936-5214. - ELETTRONICO. - 2011:18(2011), pp. 2745-2749. [10.1055/s-0031-1289516]
Organocatalytic Asymmetric Wittig Reactions: Generation of Enantioenriched Axially Chiral Olefins Breaking a Symmetry Plane
Giacomo Filippini;
2011-01-01
Abstract
The first catalytic asymmetric Wittig reaction is presented. Hydrogen-bond donors catalyze the [2+2] cycloaddition reaction between stabilized phosphorus ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.File in questo prodotto:
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