State of energy of ventricular flow: A cause or the first indicator of adverse remodeling?

Ventricular remodeling is characterized as a set of molecular, cellular, and interstitial changes that occur in the heart in response to a disease or insult, which clinically manifest as changes in size, mass, anatomy, and function of the heart. Overall remodeling is the culmination of a multifaceted series of transcriptional, signaling, structural, electrophysiological, and functional events occurring within the cardiac tissue. These proceedings could result in short-term benefit, but like any inflammatory processes if they remain persistent, they turn into maladaptive or adverse remodeling, and predispose to cardiovascular morbidity and mortality. Ventricular remodeling often begins as minor degradations of the heart function, which may be difficult to detect, then progressively develops, and eventually leads to full manifestations of heart failure. Identifying the primary changes that triggers the sequence of events leading to remodeling is of paramount importance to establish physics-based predictive models in cardiology.