Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for bed-ridden patients care, but it is also a ground-based spaceflight analogue used to mimic the challenges of long space missions for the human body. In both cases, it would be desirable to develop a panel of biomarkers to monitor muscle atrophy in a minimally invasive way at point of care to limit the onset of muscle loss in a personalized fashion.

Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy

Monti, Elena;Giacomello, Emiliana
Membro del Collaboration Group
;
Biolo, Gianni
Membro del Collaboration Group
;
Sandri, Marco;
2023-01-01

Abstract

Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for bed-ridden patients care, but it is also a ground-based spaceflight analogue used to mimic the challenges of long space missions for the human body. In both cases, it would be desirable to develop a panel of biomarkers to monitor muscle atrophy in a minimally invasive way at point of care to limit the onset of muscle loss in a personalized fashion.
2023
14-dic-2022
Pubblicato
https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13146
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891930/
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/3036918
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