Background: We characterized oncological outcomes of head and neck verrucous carcinomas (HNVC) and explored treatment-associated outcomes. Methods: Medical records of 106 HNVC patients (1994-2024) were reviewed, analyzing clinical history, tumor characteristics, treatment modality, and outcomes. Results: Among 106 patients, 101 underwent surgery. Five-year overall survival and recurrence-free survival were 82.2% and 85.3%, respectively. Cox regression identified age ≥ 65 years as significantly increasing recurrence risk (HR = 5.989; 95% CI 2.02-17.77), while tobacco consumption decreased risk (HR = 0.309; 95% CI 0.12-0.81). Clinical T stage influenced recurrence: cT2 (HR = 0.22), cT3 (HR = 1.366), cT4 (HR = 1.525). Compared with local resection, partial organ resection (HR = 0.841) and total organ resection (HR = 0.501) showed lower recurrence rates. Conclusion: HNVC demonstrates excellent five-year survival. Surgery remains the primary treatment, with wider resections significantly reducing recurrence risk, emphasizing the importance of achieving clear margins for durable local control.
Head and Neck Verrucous Carcinoma: A European Multicenter Retrospective Study / Schrooyen, A., Vaira, L.A., Boscolo-Rizzo, P., Brunet, A., Marí, A., Saibene, A.M., Carsuzaa, F., Spinato, L., Rodriguez, A., Hans, S., Maniaci, A., Chiesa-Estomba, C.M., Briganti, G., Dequanter, D., Lechien, J.R.. - In: HEAD & NECK. - ISSN 1043-3074. - (2026), pp. 1-8. [Epub ahead of print] [10.1002/hed.70423]
Head and Neck Verrucous Carcinoma: A European Multicenter Retrospective Study
Vaira, Luigi Angelo;Boscolo-Rizzo, Paolo;
2026-01-01
Abstract
Background: We characterized oncological outcomes of head and neck verrucous carcinomas (HNVC) and explored treatment-associated outcomes. Methods: Medical records of 106 HNVC patients (1994-2024) were reviewed, analyzing clinical history, tumor characteristics, treatment modality, and outcomes. Results: Among 106 patients, 101 underwent surgery. Five-year overall survival and recurrence-free survival were 82.2% and 85.3%, respectively. Cox regression identified age ≥ 65 years as significantly increasing recurrence risk (HR = 5.989; 95% CI 2.02-17.77), while tobacco consumption decreased risk (HR = 0.309; 95% CI 0.12-0.81). Clinical T stage influenced recurrence: cT2 (HR = 0.22), cT3 (HR = 1.366), cT4 (HR = 1.525). Compared with local resection, partial organ resection (HR = 0.841) and total organ resection (HR = 0.501) showed lower recurrence rates. Conclusion: HNVC demonstrates excellent five-year survival. Surgery remains the primary treatment, with wider resections significantly reducing recurrence risk, emphasizing the importance of achieving clear margins for durable local control.Pubblicazioni consigliate
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