Concomitant oral and genital mucosal involvement in classical Sweet syndrome

Sweet syndrome (SS) is a rare neutrophilic dermatosis in which mucosal involvement is uncommon and traditionally regarded as a feature of the malignancy-associated subtype. We describe a 39-year-old woman with classical SS presenting with fever, painful papulonodular and vesiculopustular skin lesions, and simultaneous oral and genital mucosal ulcers. Extensive infectious, autoimmune and oncologic work-up was negative, and skin biopsy showed a dense dermal neutrophilic infiltrate without vasculitis. Systemic corticosteroids led to rapid improvement. This case suggests that mucosal involvement may also occur in classical SS.