In order to investigate the molecular features involved in sigma receptors (r-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards r1- and r2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at l-opioid, d-opioid and j-opioid receptors. Biological results are herein presented and discussed.
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2) / D., R., M., U., A., P., M., S., Zampieri, D., Mamolo, M.G., C., L., Zanette, C., Florio, C., D., S., B., W., O., A., Collina, S.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 1464-3391. - STAMPA. - 18:(2010), pp. 1204-1212. [10.1016/j.bmc.2009.12.039]
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2)
ZAMPIERI, DANIELE;MAMOLO, MARIA GRAZIA;ZANETTE, CATERINA;FLORIO, CHIARA;COLLINA, SIMONA
2010-01-01
Abstract
In order to investigate the molecular features involved in sigma receptors (r-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards r1- and r2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at l-opioid, d-opioid and j-opioid receptors. Biological results are herein presented and discussed.Pubblicazioni consigliate
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