In order to investigate the molecular features involved in sigma receptors (r-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards r1- and r2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at l-opioid, d-opioid and j-opioid receptors. Biological results are herein presented and discussed.
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2)
ZAMPIERI, DANIELE;MAMOLO, MARIA GRAZIA;ZANETTE, CATERINA;FLORIO, CHIARA;COLLINA, SIMONA
2010-01-01
Abstract
In order to investigate the molecular features involved in sigma receptors (r-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards r1- and r2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at l-opioid, d-opioid and j-opioid receptors. Biological results are herein presented and discussed.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
