We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease / Fasano, A; Not, Tarcisio; Wang, W; Uzzau, S; Berti, I; Tommasini, A; Goldblum, Se. - In: THE LANCET. - ISSN 0140-6736. - 355:(2000), pp. 1518-1519. [10.1016/S0140-6736(00)02169-3]
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.
NOT, TARCISIO;TOMMASINI A;
2000-01-01
Abstract
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.Pubblicazioni consigliate
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