Prostate Tumour-Inducing gene-1 analysis in human prostate cancer cells and tissue in relation to Mycoplasma infection

The potential role of PTI-1, in the natural story of prostate adenocarcinoma remains to be fullydetermined. PTI-1 expression was evaluated in human prostate cancer cell lines and in paraffinembeddedarchive tissues. PTI-1 expression was found in Mycoplasma infected but not in noninfectedcells. The lack of PTI-1 expression was also confirmed in fixed and paraffin-embeddedhuman cancer prostate biopsies. The overall data indicate that, in prostate tumor cell lines, PTI-1 presence parallels Mycoplasma infection suggesting that PTI-1 might not necessarily play amajor role in the onset of prostate tumorigenesis.