In patients undergoing PCI for acute coronary syndromes, a 7-day double-dose clopidogrel regimen was associated with a reduction in cardiovascular events and stent thrombosis compared with the standard dose. Effi cacy and safety did not diff er between high-dose and low-dose aspirin. A double-dose clopidogrel regimen can be considered for all patients with acute coronary syndromes treated with an early invasive strategy and intended early PCI.
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial / Mehta, Sr; Tanguay, Jf; Eikelboom, Jw; Jolly, Ss; Joyner, Cd; Granger, Cb; Faxon, Dp; Rupprecht, Hj; Budaj, A; Avezum, A; Widimsky, P; Steg, Pg; Bassand, Jp; Montalescot, G; Macaya, C; Di Pasquale, G; Niemela, K; Ajani, Ae; White, Hd; Chrolavicius, S; Gao, P; Fox, Ka; Yusuf, S; CURRENT OASIS, 7 trial investigators; Pizzolato, Gilberto. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 376:(2010), pp. 1233-1243. [10.1016/S0140-6736(10)61088-4]
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.
PIZZOLATO, GILBERTO
2010-01-01
Abstract
In patients undergoing PCI for acute coronary syndromes, a 7-day double-dose clopidogrel regimen was associated with a reduction in cardiovascular events and stent thrombosis compared with the standard dose. Effi cacy and safety did not diff er between high-dose and low-dose aspirin. A double-dose clopidogrel regimen can be considered for all patients with acute coronary syndromes treated with an early invasive strategy and intended early PCI.Pubblicazioni consigliate
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