In patients undergoing PCI for acute coronary syndromes, a 7-day double-dose clopidogrel regimen was associated with a reduction in cardiovascular events and stent thrombosis compared with the standard dose. Effi cacy and safety did not diff er between high-dose and low-dose aspirin. A double-dose clopidogrel regimen can be considered for all patients with acute coronary syndromes treated with an early invasive strategy and intended early PCI.
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial / Mehta, S.r., Tanguay, J.f., Eikelboom, J.w., Jolly, S.s., Joyner, C.d., Granger, C.b., Faxon, D.p., Rupprecht, H.j., Budaj, A., Avezum, A., Widimsky, P., Steg, P.g., Bassand, J.p., Montalescot, G., Macaya, C., Di Pasquale, G., Niemela, K., Ajani, A.e., White, H.d., Chrolavicius, S., et al.. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 376:(2010), pp. 1233-1243. [10.1016/S0140-6736(10)61088-4]
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.
PIZZOLATO, GILBERTO
2010-01-01
Abstract
In patients undergoing PCI for acute coronary syndromes, a 7-day double-dose clopidogrel regimen was associated with a reduction in cardiovascular events and stent thrombosis compared with the standard dose. Effi cacy and safety did not diff er between high-dose and low-dose aspirin. A double-dose clopidogrel regimen can be considered for all patients with acute coronary syndromes treated with an early invasive strategy and intended early PCI.Pubblicazioni consigliate
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