OBJECTIVES: • To investigate cancer-related outcomes of chromophobe renal cell carcinoma (ChRCC) in a large multicentre dataset. • To determine prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS) for this RCC histological type. PATIENTS AND METHODS: • In all, 291 patients with ChRCC were identified from a multi-institutional retrospective database including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007. • Univariable and multivariable Cox regression models were used to identify prognostic factors predictive of RFS and CSS after surgery for ChRCC. RESULTS: • At a median follow-up of 44 months, 25 patients (8.6%) had disease recurrence and 18 patients (6.2%) died from disease.• The 5-year RFS and CSS rates were 89.3% and 93%, respectively. • Gender ( P = 0.014), clinical T stage ( P = 0.017), pathological T stage ( P = 0.003), and sarcomatoid differentiation ( P = 0.032) were independent predictors of RFS at multivariable analysis. • For CSS, there was an independent prognostic role for gender ( P = 0.032) and T stage ( P = 0.019) among the clinical variables and for T stage ( P = 0.016), N/M stage ( P = 0.023), and sarcomatoid differentiation ( P = 0.015) among the pathological variables. CONCLUSIONS: • Patients with ChRCC have a low risk of tumour progression, metastasis, and cancer-specific death. • Patient gender, clinical and pathological tumour stage, and sarcomatoid differentiation are significant predictors of RFS and CSS for ChRCC.
Chromophobe renal cell carcinoma (RCC): Oncological outcomes and prognostic factors in a large multicentre series / Volpe, A.; Novara, G.; Antonelli, A.; Bertini, R.; Billia, M.; Carmignani, G.; Cosciani Cunico, S.; Longo, N.; Martignoni, G.; Minervini, A.; Mirone, V.; Simonato, A.; Terrone, C.; Zattoni, F.; Ficarra, V.; De Cobelli, O.; Martorana, G.; Schiavina, R.; Corti, S.; Simeone, C.; Castelli, M.; Cimino, S.; Favilla, V.; Morgia, G.; Imbimbo, C.; Carini, M.; Masieri, L.; Serni, S.; Oneto, F.; Varca, V.; Rocco, F.; Valotto, C.; Costantini, E.; Porena, M.; Zucchi, A.; Ciciliato, Stefano; Lampropoulou, N.; Siracusano, Salvatore; Fontana, D.; Gontero, P.; Tizzani, A.; Artibani, W.; Brunelli, M.; Montorsi, F.; Petralia, G.; Roscigno, M.; Strada, E.. - In: BJU INTERNATIONAL. - ISSN 1464-410X. - STAMPA. - 110:(2012), pp. 76-83.
Chromophobe renal cell carcinoma (RCC): Oncological outcomes and prognostic factors in a large multicentre series
CICILIATO, STEFANO;SIRACUSANO, SALVATORE;
2012-01-01
Abstract
OBJECTIVES: • To investigate cancer-related outcomes of chromophobe renal cell carcinoma (ChRCC) in a large multicentre dataset. • To determine prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS) for this RCC histological type. PATIENTS AND METHODS: • In all, 291 patients with ChRCC were identified from a multi-institutional retrospective database including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007. • Univariable and multivariable Cox regression models were used to identify prognostic factors predictive of RFS and CSS after surgery for ChRCC. RESULTS: • At a median follow-up of 44 months, 25 patients (8.6%) had disease recurrence and 18 patients (6.2%) died from disease.• The 5-year RFS and CSS rates were 89.3% and 93%, respectively. • Gender ( P = 0.014), clinical T stage ( P = 0.017), pathological T stage ( P = 0.003), and sarcomatoid differentiation ( P = 0.032) were independent predictors of RFS at multivariable analysis. • For CSS, there was an independent prognostic role for gender ( P = 0.032) and T stage ( P = 0.019) among the clinical variables and for T stage ( P = 0.016), N/M stage ( P = 0.023), and sarcomatoid differentiation ( P = 0.015) among the pathological variables. CONCLUSIONS: • Patients with ChRCC have a low risk of tumour progression, metastasis, and cancer-specific death. • Patient gender, clinical and pathological tumour stage, and sarcomatoid differentiation are significant predictors of RFS and CSS for ChRCC.Pubblicazioni consigliate
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