OBJECTIVES: • To investigate cancer-related outcomes of chromophobe renal cell carcinoma (ChRCC) in a large multicentre dataset. • To determine prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS) for this RCC histological type. PATIENTS AND METHODS: • In all, 291 patients with ChRCC were identified from a multi-institutional retrospective database including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007. • Univariable and multivariable Cox regression models were used to identify prognostic factors predictive of RFS and CSS after surgery for ChRCC. RESULTS: • At a median follow-up of 44 months, 25 patients (8.6%) had disease recurrence and 18 patients (6.2%) died from disease.• The 5-year RFS and CSS rates were 89.3% and 93%, respectively. • Gender ( P = 0.014), clinical T stage ( P = 0.017), pathological T stage ( P = 0.003), and sarcomatoid differentiation ( P = 0.032) were independent predictors of RFS at multivariable analysis. • For CSS, there was an independent prognostic role for gender ( P = 0.032) and T stage ( P = 0.019) among the clinical variables and for T stage ( P = 0.016), N/M stage ( P = 0.023), and sarcomatoid differentiation ( P = 0.015) among the pathological variables. CONCLUSIONS: • Patients with ChRCC have a low risk of tumour progression, metastasis, and cancer-specific death. • Patient gender, clinical and pathological tumour stage, and sarcomatoid differentiation are significant predictors of RFS and CSS for ChRCC.

Chromophobe renal cell carcinoma (RCC): Oncological outcomes and prognostic factors in a large multicentre series

CICILIATO, STEFANO;SIRACUSANO, SALVATORE;
2012-01-01

Abstract

OBJECTIVES: • To investigate cancer-related outcomes of chromophobe renal cell carcinoma (ChRCC) in a large multicentre dataset. • To determine prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS) for this RCC histological type. PATIENTS AND METHODS: • In all, 291 patients with ChRCC were identified from a multi-institutional retrospective database including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007. • Univariable and multivariable Cox regression models were used to identify prognostic factors predictive of RFS and CSS after surgery for ChRCC. RESULTS: • At a median follow-up of 44 months, 25 patients (8.6%) had disease recurrence and 18 patients (6.2%) died from disease.• The 5-year RFS and CSS rates were 89.3% and 93%, respectively. • Gender ( P = 0.014), clinical T stage ( P = 0.017), pathological T stage ( P = 0.003), and sarcomatoid differentiation ( P = 0.032) were independent predictors of RFS at multivariable analysis. • For CSS, there was an independent prognostic role for gender ( P = 0.032) and T stage ( P = 0.019) among the clinical variables and for T stage ( P = 0.016), N/M stage ( P = 0.023), and sarcomatoid differentiation ( P = 0.015) among the pathological variables. CONCLUSIONS: • Patients with ChRCC have a low risk of tumour progression, metastasis, and cancer-specific death. • Patient gender, clinical and pathological tumour stage, and sarcomatoid differentiation are significant predictors of RFS and CSS for ChRCC.
2012
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2556933
 Avviso

Registrazione in corso di verifica.
La registrazione di questo prodotto non è ancora stata validata in ArTS.

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 124
  • ???jsp.display-item.citation.isi??? 113
social impact