We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95\% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95\% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.
Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients / C. B., Filho; F. F., Rodrigues; Segat, Ludovica; A. M., Fonseca; J., Araujo; C., Arahata; L., Pontes; L., Vilar; J. L., De; Crovella, Sergio. - In: INTERNATIONAL JOURNAL OF IMMUNOGENETICS. - ISSN 1744-3121. - 39:(2012), pp. 357-361. [10.1111/j.1744-313X.2012.01102.x]
Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.
SEGAT, LUDOVICA;CROVELLA, SERGIO
2012-01-01
Abstract
We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95\% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95\% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.Pubblicazioni consigliate
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