A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.
PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies
ZACCHIGNA, MARINA;CATENI, FRANCESCA;DRIOLI, Sara;PROCIDA, GIUSEPPE;
2014-01-01
Abstract
A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.File in questo prodotto:
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