Gastric bypass-induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Systemic inflammation contributes to obesity-associated complications. The short pentraxin C-reactive protein (CRP) is a validated inflammatory marker, whereas long pentraxin-3 (PTX3) limits inflammation and is adaptively stimulated by proinflammatory cytokines in vitro. Severely obese (SO) patients (body mass index [BMI]>40] have the highest obesity-associated complications and increasingly undergo surgical treatment. SO-associated changes in plasma PTX3 and their interactions with systemic inflammation are, however, unknown.



Titolo: Gastric bypass-induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers
Autori: 
BARAZZONI, ROCCO
PALMISANO, SILVIA
GORTAN CAPPELLARI, GIANLUCA
GIURICIN, MICHELA
MORETTI, ELISA
VINCI, PIERANDREA
SEMOLIC, ANNA MARIA
GUARNIERI, GIANFRANCO
ZANETTI, MICHELA
de Manzini, Nicolo'
Data di pubblicazione: 2016
Rivista: 
SURGERY FOR OBESITY AND RELATED DISEASES  
Abstract: Systemic inflammation contributes to obesity-associated complications. The short pentraxin C-reactive protein (CRP) is a validated inflammatory marker, whereas long pentraxin-3 (PTX3) limits inflammation and is adaptively stimulated by proinflammatory cytokines in vitro. Severely obese (SO) patients (body mass index [BMI]>40] have the highest obesity-associated complications and increasingly undergo surgical treatment. SO-associated changes in plasma PTX3 and their interactions with systemic inflammation are, however, unknown.
Handle: http://hdl.handle.net/11368/2844694
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.soard.2015.04.013
URL: http://www.sciencedirect.com/science/article/pii/S155072891500115X
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