Neural-interfaces rely on the ability of electrodes to transduce stimuli into electrical patterns delivered to the brain. In addition to sensitivity to the stimuli, stability in the operating conditions and efficient charge transfer to neurons, the electrodes should not alter the physiological properties of the target tissue. Graphene is emerging as a promising material for neuro-interfacing applications, given its outstanding physico-chemical properties. Here, we use graphene-based substrates (GBSs) to interface neuronal growth. We test our GBSs on brain cell cultures by measuring functional and synaptic integrity of the emerging neuronal networks. We show that GBSs are permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.

Graphene-Based Interfaces Do Not Alter Target Nerve Cells

FABBRO, ALESSANDRA;SCAINI, DENIS;CELLOT, GIADA;BOSI, Susanna;BALLERINI, Laura;PRATO, MAURIZIO
2015-01-01

Abstract

Neural-interfaces rely on the ability of electrodes to transduce stimuli into electrical patterns delivered to the brain. In addition to sensitivity to the stimuli, stability in the operating conditions and efficient charge transfer to neurons, the electrodes should not alter the physiological properties of the target tissue. Graphene is emerging as a promising material for neuro-interfacing applications, given its outstanding physico-chemical properties. Here, we use graphene-based substrates (GBSs) to interface neuronal growth. We test our GBSs on brain cell cultures by measuring functional and synaptic integrity of the emerging neuronal networks. We show that GBSs are permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.
http://pubs.acs.org/doi/abs/10.1021/acsnano.5b05647
File in questo prodotto:
File Dimensione Formato  
Graphene-Based Interfaces Do Not Alter Target Nerve Cells.pdf

Accesso chiuso

Descrizione: pdf editoriale
Tipologia: Documento in Versione Editoriale
Licenza: Digital Rights Management non definito
Dimensione 4.27 MB
Formato Adobe PDF
4.27 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
2015_ACS Nano.pdf

Open Access dal 23/12/2016

Descrizione: pdf post-print
Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Digital Rights Management non definito
Dimensione 4.43 MB
Formato Adobe PDF
4.43 MB Adobe PDF Visualizza/Apri
2860012_2015_ACS Nano-PostPrint.pdf

accesso aperto

Descrizione: Post Print VQR3
Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Digital Rights Management non definito
Dimensione 4.96 MB
Formato Adobe PDF
4.96 MB Adobe PDF Visualizza/Apri
2860012_Graphene-Based Interfaces Do Not Alter Target Nerve Cells-PostPrint.pdf

accesso aperto

Descrizione: Post Print VQR3
Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Digital Rights Management non definito
Dimensione 4.8 MB
Formato Adobe PDF
4.8 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2860012
Citazioni
  • ???jsp.display-item.citation.pmc??? 38
  • Scopus 137
  • ???jsp.display-item.citation.isi??? 127
social impact