ArTS Archivio della ricerca di Trieste
ArTS è il sistema di gestione integrata dei dati della ricerca adottato dall' Università degli Studi di Trieste
EnglishBackground: Immune mechanisms have been implicated in nonceliac gluten sensitivity (NCGS), a con- dition characterized by intestinal and/or extraintestinal symptoms caused by the ingestion of gluten in non-celiac/non-wheat allergic individuals. Aims: We investigated innate and adaptive immunity in self-reported NCGS versus celiac disease (CD). Methods: In the supernatants of ex vivo-cultured duodenal biopsies from 14 self-reported NCGS patients, 9 untreated and 10 treated CD patients, and 12 controls we detected innate cytokines – interleukin (IL)- 15, tumor necrosis factor-?, IL-1?, IL-6, IL-12p70, IL-23, IL-27, IL-32?, thymic stromal lymphopoietin (TSLP), IFN-?-, adaptive cytokines – interferon (IFN)-?, IL-17A, IL-4, IL-5, IL-10, IL-13-, chemokines – IL-8, CCL1, CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL10-, granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF). Results: Mucosal innate and adaptive cytokines, chemokines and growth factors did not differ between self-reported NCGS, treated CD and controls. On the contrary, IL-6, IL-15, IL-27, IFN-?, IFN-?, IL-17A, IL- 23, G-CSF, GM-CSF, IL-8, CCL1 and CCL4 were significantly higher in untreated CD than in self-reported NCGS, treated CD and controls, while TSLP was significantly lower in untreated CD than in self-reported NCGS, treated CD and controls. Conclusion: In our hands, patients with self-reported NCGS showed no abnormalities of the mucosal immune response.
| Titolo: | Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease | |
| Autori: | ||
| Data di pubblicazione: | 2016 | |
| Stato di pubblicazione: | Pubblicato | |
| Rivista: | ||
| Abstract: | Background: Immune mechanisms have been implicated in nonceliac gluten sensitivity (NCGS), a con- dition characterized by intestinal and/or extraintestinal symptoms caused by the ingestion of gluten in non-celiac/non-wheat allergic individuals. Aims: We investigated innate and adaptive immunity in self-reported NCGS versus celiac disease (CD). Methods: In the supernatants of ex vivo-cultured duodenal biopsies from 14 self-reported NCGS patients, 9 untreated and 10 treated CD patients, and 12 controls we detected innate cytokines – interleukin (IL)- 15, tumor necrosis factor-?, IL-1?, IL-6, IL-12p70, IL-23, IL-27, IL-32?, thymic stromal lymphopoietin (TSLP), IFN-?-, adaptive cytokines – interferon (IFN)-?, IL-17A, IL-4, IL-5, IL-10, IL-13-, chemokines – IL-8, CCL1, CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL10-, granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF). Results: Mucosal innate and adaptive cytokines, chemokines and growth factors did not differ between self-reported NCGS, treated CD and controls. On the contrary, IL-6, IL-15, IL-27, IFN-?, IFN-?, IL-17A, IL- 23, G-CSF, GM-CSF, IL-8, CCL1 and CCL4 were significantly higher in untreated CD than in self-reported NCGS, treated CD and controls, while TSLP was significantly lower in untreated CD than in self-reported NCGS, treated CD and controls. Conclusion: In our hands, patients with self-reported NCGS showed no abnormalities of the mucosal immune response. | |
| Handle: | http://hdl.handle.net/11368/2880923 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.dld.2016.03.024 | |
| URL: | http://www.sciencedirect.com/science/article/pii/S159086581530428X | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Dig liver dis.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia | |
| 2880923_Dig liver dis-PostPrint.pdf | Post Print VQR3 - This is an Accepted Manuscript of an article published by Elsevier in Digestive and Liver Disease on 7 Apr 2016, available online: https://doi.org/10.1016/j.dld.2016.03.024 | Bozza finale post-referaggio (post-print) |  | Open Access Visualizza/Apri |
