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EnglishBile acids lithocholic acid (LCA) and ursodeoxycholic acid (UDCA) together with trametenolic acid (TMA) were used as starting materials for the preparation of new derivatives bearing a guanidine moiety in their side chain. The derivatives were synthesized through modification at the oxygenated carbon C-3/C-7 and at the carbonyl carbon C-24/C-21. The reactions showed yields ranging from 40 % to 96 %. The structures of all compounds obtained were identified on the basis of their spectral data (IR, MS, 1D- and 2D-NMR). The activity of bile acids, trametenolic acid and derivatives was evaluated against the growth of S. aureus, B. subtilis and M. smegmatis. The derivative 3α-hydroxy-23-guanidino-5β-cholane showed the best activity, with MIC values of 12.5 μM against S. aureus, 5 μM against B. subtilis and 50 μM against M. smegmatis. The cytotoxic activity of bile acids, trametenolic acid and derivatives was also evaluated against HT-29 cell line.
| Titolo: | Cholane and Lanostane Derivatives: Antimicrobial Evaluation |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Abstract: | Bile acids lithocholic acid (LCA) and ursodeoxycholic acid (UDCA) together with trametenolic acid (TMA) were used as starting materials for the preparation of new derivatives bearing a guanidine moiety in their side chain. The derivatives were synthesized through modification at the oxygenated carbon C-3/C-7 and at the carbonyl carbon C-24/C-21. The reactions showed yields ranging from 40 % to 96 %. The structures of all compounds obtained were identified on the basis of their spectral data (IR, MS, 1D- and 2D-NMR). The activity of bile acids, trametenolic acid and derivatives was evaluated against the growth of S. aureus, B. subtilis and M. smegmatis. The derivative 3α-hydroxy-23-guanidino-5β-cholane showed the best activity, with MIC values of 12.5 μM against S. aureus, 5 μM against B. subtilis and 50 μM against M. smegmatis. The cytotoxic activity of bile acids, trametenolic acid and derivatives was also evaluated against HT-29 cell line. |
| Handle: | http://hdl.handle.net/11368/2883448 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/slct.201600556 |
| URL: | http://dx.doi.org/10.1002/slct.201600556 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Cholane.pdf | Articolo principale | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
| slct201600556-sup-0001-misc_information.pdf | Supporting information | Altro materiale allegato | Digital Rights Management non definito | Administrator Richiedi una copia |
http://hdl.handle.net/11368/2883448
