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EnglishHepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.
| Titolo: | HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection |
| Autori: | |
| Data di pubblicazione: | 2017 |
| Rivista: | |
| Abstract: | Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection. |
| Handle: | http://hdl.handle.net/11368/2893972 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/tan.12959 |
| URL: | http://onlinelibrary.wiley.com/doi/10.1111/tan.12959/abstract;jsessionid=8E9667527A035A12FBC203E17CED3E9D.f03t01 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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| HLA-G_HCV_2017-HLA.pdf | HLA-G_HCV | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
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