Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.
HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection / Catamo, Eulalia; Zupin, Luisa; Freato, N.; Polesello, Vania; Celsi, F.; Croce', Saveria; Masutti, F.; Pozzato, Gabriele; Segat, Ludovica; Crovella, Sergio. - In: HLA. - ISSN 2059-2302. - 89:3(2017), pp. 135-142. [10.1111/tan.12959]
HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection
CATAMO, EULALIA;ZUPIN, LUISA;POLESELLO, VANIA;CROCE', Saveria;POZZATO, GABRIELE;SEGAT, LUDOVICA;CROVELLA, SERGIO
2017-01-01
Abstract
Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.| File | Dimensione | Formato | |
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