Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.

HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection

CATAMO, EULALIA;ZUPIN, LUISA;POLESELLO, VANIA;CROCE', Saveria;POZZATO, GABRIELE;SEGAT, LUDOVICA;CROVELLA, SERGIO
2017

Abstract

Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.
HLA
http://onlinelibrary.wiley.com/doi/10.1111/tan.12959/abstract;jsessionid=8E9667527A035A12FBC203E17CED3E9D.f03t01
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2893972
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