Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.
HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection
CATAMO, EULALIA;ZUPIN, LUISA;POLESELLO, VANIA;CROCE', Saveria;POZZATO, GABRIELE;SEGAT, LUDOVICA;CROVELLA, SERGIO
2017-01-01
Abstract
Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.File in questo prodotto:
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HLA-G_HCV_2017-HLA.pdf
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