Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.
HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection
CATAMO, EULALIA;ZUPIN, LUISA;POLESELLO, VANIA;CROCE', Saveria;POZZATO, GABRIELE;SEGAT, LUDOVICA;CROVELLA, SERGIO
2017
Abstract
Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized its involvement in susceptibility to HCV infection.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
HLA-G_HCV_2017-HLA.pdf
non disponibili
Descrizione: HLA-G_HCV
Tipologia:
Documento in Versione Editoriale
Licenza:
Digital Rights Management non definito
Dimensione
919.97 kB
Formato
Adobe PDF
|
919.97 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
