We investigated the possible association between PRF1 gene polymorphisms and HIV-1 vertical transmission in Brazilian children by analyzing PRF1 gene coding and untranslated regions in 173 perinatally infected children (HIV+), 51 exposed uninfected (HIV-), and 171 HIV-unexposed uninfected children. Seven single nucleotide polymorphisms were identified in our samples. The rs885822 C allele and CC genotype were significantly more frequent in HIV-negative than in HIV-positive patients and associated with a protective effect toward HIV vertical transmission.
A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children / Padovan, Lara; Segat, Ludovica; Crovella, Sergio. - In: AIDS. - ISSN 1473-5571. - 25:4(2011), pp. 535-537. [10.1097/QAD.0b013e3283428b7c]
A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children
PADOVAN, LARA;SEGAT, LUDOVICA;CROVELLA, SERGIO
2011-01-01
Abstract
We investigated the possible association between PRF1 gene polymorphisms and HIV-1 vertical transmission in Brazilian children by analyzing PRF1 gene coding and untranslated regions in 173 perinatally infected children (HIV+), 51 exposed uninfected (HIV-), and 171 HIV-unexposed uninfected children. Seven single nucleotide polymorphisms were identified in our samples. The rs885822 C allele and CC genotype were significantly more frequent in HIV-negative than in HIV-positive patients and associated with a protective effect toward HIV vertical transmission.Pubblicazioni consigliate
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