Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1.

A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection

PONTILLO, Alessandra;SEGAT, LUDOVICA;ATHANASAKIS, EMMANOUIL;CROVELLA, SERGIO
2010

Abstract

Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1.
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2894060
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