A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection

Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1.



Titolo: A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection
Autori: 
PONTILLO, Alessandra
SEGAT, LUDOVICA
ATHANASAKIS, EMMANOUIL
CROVELLA, SERGIO
mostra contributor esterni 
Data di pubblicazione: 2010
Rivista: 
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES  
Abstract: Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1.
Handle: http://hdl.handle.net/11368/2894060
Digital Object Identifier (DOI): http://dx.doi.org/10.1097/QAI.0b013e3181dd17d4
Appare nelle tipologie:1.1 Articolo in Rivista

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