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EnglishHerein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection.
| Titolo: | Cubosomes for in vivo fluorescence lifetime imaging | |
| Autori: | ||
| Data di pubblicazione: | 2017 | |
| Rivista: | ||
| Abstract: | Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection. | |
| Handle: | http://hdl.handle.net/11368/2905894 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1088/1361-6528/28/5/055102 | |
| URL: | http://iopscience.iop.org/article/10.1088/1361-6528/28/5/055102/meta;jsessionid=C86F7A4134F6D611AA0E1290714C88BC.c1.iopscience.cld.iop.org | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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|---|---|---|---|---|
| Biffi et al_Nanotechnology 2017.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia | |
| Cubosomes_suppdata.pdf | Supplemetary data | Altro materiale allegato | Digital Rights Management non definito | Administrator Richiedi una copia |
