Study of 1,3,5-triazine-based amidation agents and their application in condensation reactions, collagen cross-linking and polymer grafting

Amide bonds are important for the synthesis or functionalization of many biological macromolecules and a wide range of pharmaceutical products, polymers and fibers. 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM) is an unexploited amidation agent capable to work in wide pH range, water solvent and room temperature. Starting from DMTMM, this thesis focuses on the synthesis of new amidation agents, more active and stable, leading to the drafting of two patents, one of which international. Moreover, this work examines the application of these new compounds for the cross-linking of atoxic and metal-free collagen. Finally, the functionalization of polymers by DMTMM is investigated for the modification of polymer surfaces.