Based on its phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitory properties, theophylline was administered to a young girl with activated PI3Kd syndrome (APDS). We report reduced frequency of infections, decreased lymphoproliferation, and noticeable changes in immunophenotype, encouraging further trials with theophylline in children with APDS.

Theophylline as a precision therapy in a young girl with PIK3R1 immunodeficiency

Valencic E.;Conversano E.
;
Lucafo M.;Piscianz E.;Tommasini A.
2018

Abstract

Based on its phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitory properties, theophylline was administered to a young girl with activated PI3Kd syndrome (APDS). We report reduced frequency of infections, decreased lymphoproliferation, and noticeable changes in immunophenotype, encouraging further trials with theophylline in children with APDS.
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https://www.sciencedirect.com/science/article/abs/pii/S2213219818301296?via=ihub
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2964577
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