Based on its phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitory properties, theophylline was administered to a young girl with activated PI3Kd syndrome (APDS). We report reduced frequency of infections, decreased lymphoproliferation, and noticeable changes in immunophenotype, encouraging further trials with theophylline in children with APDS.
Theophylline as a precision therapy in a young girl with PIK3R1 immunodeficiency
Valencic E.;Conversano E.
;Lucafo M.;Piscianz E.;Tommasini A.
2018-01-01
Abstract
Based on its phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitory properties, theophylline was administered to a young girl with activated PI3Kd syndrome (APDS). We report reduced frequency of infections, decreased lymphoproliferation, and noticeable changes in immunophenotype, encouraging further trials with theophylline in children with APDS.File in questo prodotto:
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