‘Bioinks’ are important tools for the fabrication of artificial living-tissue constructs that are able to mimic all properties of native tissues via 3D bioprinting technologies. Bioinks are most commonly made by incorporating live cells of interest within a natural or synthetic biocompatible polymeric matrix. In oncology research, the ability to recreate a tumor microenvironment (TME) using by 3D bioprinting constitutes a promising approach for drug development, screening, and in vitro cancer modeling. Here, we review the different types of bioink used for 3D bioprinting, with a focus on its application in cancer management. In addition, we consider the fabrication of bioink using customized materials/cells and their properties in the field of cancer drug discovery.

Bioink: a 3D-bioprinting tool for anticancer drug discovery and cancer management / Tiwari, A. P.; Thorat, N. D.; Pricl, S.; Patil, R. M.; Rohiwal, S.; Townley, H.. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - STAMPA. - 26:7(2021), pp. 1574-1590. [10.1016/j.drudis.2021.03.010]

Bioink: a 3D-bioprinting tool for anticancer drug discovery and cancer management

Pricl S.;
2021-01-01

Abstract

‘Bioinks’ are important tools for the fabrication of artificial living-tissue constructs that are able to mimic all properties of native tissues via 3D bioprinting technologies. Bioinks are most commonly made by incorporating live cells of interest within a natural or synthetic biocompatible polymeric matrix. In oncology research, the ability to recreate a tumor microenvironment (TME) using by 3D bioprinting constitutes a promising approach for drug development, screening, and in vitro cancer modeling. Here, we review the different types of bioink used for 3D bioprinting, with a focus on its application in cancer management. In addition, we consider the fabrication of bioink using customized materials/cells and their properties in the field of cancer drug discovery.
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1359644621001446-main.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Copyright Editore
Dimensione 3.55 MB
Formato Adobe PDF
3.55 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
2997251_1-s2.0-S1359644621001446-main-Post_print.pdf

Open Access dal 17/03/2022

Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Creative commons
Dimensione 4.04 MB
Formato Adobe PDF
4.04 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2997251
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 39
social impact