Aim: the aim of this case report was to compare new bone for- mation in grafting biomaterials with or without the addition of platelet-rich fibrin (PRF) by means of histomorphometric analysis. Methods: bilateral sinus augmentation surgery was performed in a patient of 50 years old with severe maxilla atrophy. Graft in left sinus was performed only with Bio-Oss®, meanwhile in right sinus Bio-Oss® with the addition of PRF was applied. Af- ter 6 months, before dental implants insertion, cylindrical bone biopsies were developed in both grafting sites (T = 0). The bo- ne obtained was prepared with the Schenk method and analyzed quantitatively with a computer software. In the sam- ples were marked and distinguished: old bone, newly formed bone, Bio-oss® and connective tissue/bone marrow. After 10 years, before implants insertion, control bone biopsies were performed and analyzed with the identical procedures (T = 1). Results: at T = 0 no quantitative differences were observed in new bone and residual biomaterial in both sites. New bone for- mation was only peripherical in the left sinus, whereas it deve- loped both peripherally and through biomaterial in the right si- nus. At T = 1 a similar new bone formation was found, however in left sinus Bio-oss® particles were still present, while in right sinus they were not. Conclusions: this case report showed that the adjunct of PRF led to a more homogeneous new bone formation and helped to complete long term biotransformation of biomaterial. Fur- ther studies are needed with a wider sample dimension to eva- luate this phenomenon.
HISTOMORPHOMETRIC ANALYSIS OF NEW BONE FORMATION AFTER BILATERAL SINUS LIFT: A CASE REPORT
Michelon F.Writing – Original Draft Preparation
;Brugnera C.Software
;Bevilacqua L.Investigation
;Maglione M.Project Administration
2022-01-01
Abstract
Aim: the aim of this case report was to compare new bone for- mation in grafting biomaterials with or without the addition of platelet-rich fibrin (PRF) by means of histomorphometric analysis. Methods: bilateral sinus augmentation surgery was performed in a patient of 50 years old with severe maxilla atrophy. Graft in left sinus was performed only with Bio-Oss®, meanwhile in right sinus Bio-Oss® with the addition of PRF was applied. Af- ter 6 months, before dental implants insertion, cylindrical bone biopsies were developed in both grafting sites (T = 0). The bo- ne obtained was prepared with the Schenk method and analyzed quantitatively with a computer software. In the sam- ples were marked and distinguished: old bone, newly formed bone, Bio-oss® and connective tissue/bone marrow. After 10 years, before implants insertion, control bone biopsies were performed and analyzed with the identical procedures (T = 1). Results: at T = 0 no quantitative differences were observed in new bone and residual biomaterial in both sites. New bone for- mation was only peripherical in the left sinus, whereas it deve- loped both peripherally and through biomaterial in the right si- nus. At T = 1 a similar new bone formation was found, however in left sinus Bio-oss® particles were still present, while in right sinus they were not. Conclusions: this case report showed that the adjunct of PRF led to a more homogeneous new bone formation and helped to complete long term biotransformation of biomaterial. Fur- ther studies are needed with a wider sample dimension to eva- luate this phenomenon.Pubblicazioni consigliate
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