A formerly developed mathematical model describing drug release from hydrophilic matrices (HMs) took into account resistance to drug release given by its dissolution and by the presence of a growing gel layer. Such a model was applied to previously reported release data obtained from HMs made of hydroxypropyl methylcellulose (HPMC), where acetaminophen was used as model drug and a cellulolytic product was added as "active" excipient to attain zero-order release kinetics. The Levich theory applied to acetaminophen intrinsic dissolution rate (IDR) data highlighted the suitability of such a drug for modeling purposes, given its good surface wettability. First assessment of the model ability to describe drug release from the abovementioned systems was carried out on partially coated matrices, representing a simplified physical frame, but results were then confirmed on uncoated systems. Experimental and model release data showed good agreement; therefore, the release-describing equation was combined with that of the global mass balance to obtain two new equations related to erosion and diffusion fronts time evolution. Changes over time in the dissolution and gel contributions to total resistance, calculated using model output parameters, highlighted that the enzyme, through its hydrolytic activity on HPMC, was responsible for a time-dependent reduction of the resistance component related to gel layer.

Modeling of drug release, erosion and diffusion fronts movement in high viscosity HPMC matrices containing a cellulolytic enzyme

Abrami, Michela;Grassi, Mario
Penultimo
;
2024-01-01

Abstract

A formerly developed mathematical model describing drug release from hydrophilic matrices (HMs) took into account resistance to drug release given by its dissolution and by the presence of a growing gel layer. Such a model was applied to previously reported release data obtained from HMs made of hydroxypropyl methylcellulose (HPMC), where acetaminophen was used as model drug and a cellulolytic product was added as "active" excipient to attain zero-order release kinetics. The Levich theory applied to acetaminophen intrinsic dissolution rate (IDR) data highlighted the suitability of such a drug for modeling purposes, given its good surface wettability. First assessment of the model ability to describe drug release from the abovementioned systems was carried out on partially coated matrices, representing a simplified physical frame, but results were then confirmed on uncoated systems. Experimental and model release data showed good agreement; therefore, the release-describing equation was combined with that of the global mass balance to obtain two new equations related to erosion and diffusion fronts time evolution. Changes over time in the dissolution and gel contributions to total resistance, calculated using model output parameters, highlighted that the enzyme, through its hydrolytic activity on HPMC, was responsible for a time-dependent reduction of the resistance component related to gel layer.
File in questo prodotto:
File Dimensione Formato  
IJP 2024 667.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Copyright Editore
Dimensione 1.18 MB
Formato Adobe PDF
1.18 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/3098100
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact