In the present study, we show that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in basal-like breast cancer subtype. HMGA1 knockdown induces the mesenchymal to epithelial transition and dramatically decreases stemness and self-renewal. Notably, HMGA1 depletion in basal-like breast cancer cell lines reduced migration and invasion in vitro and the formation of metastases in vivo.

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

PEGORARO, SILVIA;ROS, GLORIA;CIANI, YARI;SGARRA, RICCARDO;DEL SAL, GIANNINO;MANFIOLETTI, GUIDALBERTO
2013

Abstract

In the present study, we show that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in basal-like breast cancer subtype. HMGA1 knockdown induces the mesenchymal to epithelial transition and dramatically decreases stemness and self-renewal. Notably, HMGA1 depletion in basal-like breast cancer cell lines reduced migration and invasion in vitro and the formation of metastases in vivo.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2762631
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