In the present study, we show that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in basal-like breast cancer subtype. HMGA1 knockdown induces the mesenchymal to epithelial transition and dramatically decreases stemness and self-renewal. Notably, HMGA1 depletion in basal-like breast cancer cell lines reduced migration and invasion in vitro and the formation of metastases in vivo.

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

PEGORARO, SILVIA;ROS, GLORIA;CIANI, YARI;SGARRA, RICCARDO;DEL SAL, GIANNINO;MANFIOLETTI, GUIDALBERTO
2013-01-01

Abstract

In the present study, we show that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in basal-like breast cancer subtype. HMGA1 knockdown induces the mesenchymal to epithelial transition and dramatically decreases stemness and self-renewal. Notably, HMGA1 depletion in basal-like breast cancer cell lines reduced migration and invasion in vitro and the formation of metastases in vivo.
2013
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2762631
 Avviso

Registrazione in corso di verifica.
La registrazione di questo prodotto non è ancora stata validata in ArTS.

Citazioni
  • ???jsp.display-item.citation.pmc??? 68
  • Scopus 114
  • ???jsp.display-item.citation.isi??? 110
social impact