Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Fu Liang, Ng; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; Wilson, Peter W F; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G; Jackson, Anne U; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Christopher; Prins, Bram Peter; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Thériault, Sébastien; Verweij, Niek; Willems, Sara M; Zhao, Jing-Hua; Amouyel, Philippe; Connell, John; de Mutsert, Renée; Doney, Alex S F; Farrall, Martin; Menni, Cristina; Morris, Andrew D; Noordam, Raymond; Paré, Guillaume; Poulter, Neil R; Shields, Denis C; Stanton, Alice; Thom, Simon; Abecasis, Gonçalo; Amin, Najaf; Arking, Dan E; Ayers, Kristin L; Barbieri, Caterina M; Batini, Chiara; Bis, Joshua C; Blake, Tineka; Bochud, Murielle; Boehnke, Michael; Boerwinkle, Eric; Boomsma, Dorret I; Bottinger, Erwin P; Braund, Peter S; Brumat, Marco; Campbell, Archie; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C; Chauhan, Ganesh; Ciullo, Marina; Cocca, Massimiliano; Collins, Francis; Cordell, Heather J; Davies, Gail; Borst, Martin H de; Geus, Eco J de; Deary, Ian J; Deelen, Joris; Del Greco M, Fabiola; Demirkale, Cumhur Yusuf; Dörr, Marcus; Ehret, Georg B; Elosua, Roberto; Enroth, Stefan; Erzurumluoglu, A Mesut; Ferreira, Teresa; Frånberg, Mattias; Franco, Oscar H; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Goel, Anuj; Gow, Alan J; Gudnason, Vilmundur; Guo, Xiuqing; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B; Harris, Sarah E; Hartman, Catharina A; Havulinna, Aki S; Hicks, Andrew A; Hofer, Edith; Hofman, Albert; Hottenga, Jouke-Jan; Huffman, Jennifer E; Hwang, Shih-Jen; Ingelsson, Erik; James, Alan; Jansen, Rick; Jarvelin, Marjo-Riitta; Joehanes, Roby; Johansson, Åsa; Johnson, Andrew D; Joshi, Peter K; Jousilahti, Pekka; Jukema, J Wouter; Jula, Antti; Kähönen, Mika; Kathiresan, Sekar; Keavney, Bernard D; Khaw, Kay-Tee; Knekt, Paul; Knight, Joanne; Kolcic, Ivana; Kooner, Jaspal S; Koskinen, Seppo; Kristiansson, Kati; Kutalik, Zoltan; Laan, Maris; Larson, Marty; Launer, Lenore J; Lehne, Benjamin; Lehtimäki, Terho; Liewald, David C M; Lin, Li; Lind, Lars; Lindgren, Cecilia M; Liu, YongMei; Loos, Ruth J F; Lopez, Lorna M; Yingchang, Lu; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Mamasoula, Chrysovalanto; Marrugat, Jaume; Marten, Jonathan; Milaneschi, Yuri; Morgan, Anna; Morris, Andrew P; Morrison, Alanna C; Munson, Peter J; Nalls, Mike A; Nandakumar, Priyanka; Nelson, Christopher P; Niiranen, Teemu; Nolte, Ilja M; Nutile, Teresa; Oldehinkel, Albertine J; Oostra, Ben A; O'Reilly, Paul F; Org, Elin; Padmanabhan, Sandosh; Palmas, Walter; Palotie, Aarno; Pattie, Alison; Penninx, Brenda W J H; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Peter P; Nguyen, Quang Tri; Raitakari, Olli T; Ren, Meixia; Rettig, Rainer; Rice, Kenneth; Ridker, Paul M; Ried, Janina S; Riese, Harriëtte; Ripatti, Samuli; Robino, Antonietta; Rose, Lynda M; Rotter, Jerome I; Rudan, Igor; Ruggiero, Daniela; Saba, Yasaman; Sala, Cinzia F; Salomaa, Veikko; Samani, Nilesh J; Sarin, Antti-Pekka; Schmidt, Reinhold; Schmidt, Helena; Shrine, Nick; Siscovick, David; Smith, Albert V; Snieder, Harold; Sõber, Siim; Sorice, Rossella; Starr, John M; Stott, David J; Strachan, David P; Strawbridge, Rona J; Sundström, Johan; Swertz, Morris A; Taylor, Kent D; Teumer, Alexander; Tobin, Martin D; Tomaszewski, Maciej; Toniolo, Daniela; Traglia, Michela; Trompet, Stella; Tuomilehto, Jaakko; Tzourio, Christophe; Uitterlinden, André G; Vaez, Ahmad; van der Most, Peter J; van Duijn, Cornelia M; Vergnaud, Anne-Claire; Verwoert, Germaine C; Vitart, Veronique; Völker, Uwe; Vollenweider, Peter; Vuckovic, Dragana; Watkins, Hugh; Wild, Sarah H; Willemsen, Gonneke; Wilson, James F; Wright, Alan F; Yao, Jie; Zemunik, Tatijana; Zhang, Weihua; Attia, John R; Butterworth, Adam S; Chasman, Daniel I; Conen, David; Cucca, Francesco; Danesh, John; Hayward, Caroline; Howson, Joanna M M; Laakso, Markku; Lakatta, Edward G; Langenberg, Claudia; Melander, Olle; Mook-Kanamori, Dennis O; Palmer, Colin N A; Risch, Lorenz; Scott, Robert A; Scott, Rodney J; Sever, Peter; Spector, Tim D; van der Harst, Pim; Wareham, Nicholas J; Zeggini, Eleftheria; Levy, Daniel; Munroe, Patricia B; Newton-Cheh, Christopher; Brown, Morris J; Metspalu, Andres; Hung, Adriana M; O'Donnell, Christopher J; Edwards, Todd L; Psaty, Bruce M; Tzoulaki, Ioanna; Barnes, Michael R; Wain, Louise V; Elliott, Paul; Caulfield, Mark J

doi:10.1038/s41588-018-0205-x

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Titolo:	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Autori:	Evangelou, Evangelos Warren, Helen R Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P Karaman, Ibrahim Ng, Fu Liang Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N Giri, Ayush Velez Edwards, Digna R Sun, Yan V Cho, Kelly Gaziano, J Michael Wilson, Peter W F Tsao, Philip S Kovesdy, Csaba P Esko, Tonu Mägi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stéphanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G Jackson, Anne U Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Thériault, Sébastien Verweij, Niek Willems, Sara M Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renée Doney, Alex S F Farrall, Martin Menni, Cristina Morris, Andrew D Noordam, Raymond Paré, Guillaume Poulter, Neil R Shields, Denis C Stanton, Alice Thom, Simon Abecasis, Gonçalo Amin, Najaf Arking, Dan E Ayers, Kristin L BARBIERI, CATERINA MARIA Batini, Chiara Bis, Joshua C Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I Bottinger, Erwin P Braund, Peter S BRUMAT, MARCO Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C Chauhan, Ganesh Ciullo, Marina COCCA, MASSIMILIANO Collins, Francis Cordell, Heather J Davies, Gail Borst, Martin H de Geus, Eco J de Deary, Ian J Deelen, Joris Del Greco M, Fabiola Demirkale, Cumhur Yusuf Dörr, Marcus Ehret, Georg B Elosua, Roberto Enroth, Stefan Erzurumluoglu, A Mesut Ferreira, Teresa Frånberg, Mattias Franco, Oscar H GANDIN, ILARIA GASPARINI, PAOLO Giedraitis, Vilmantas Gieger, Christian GIROTTO, GIORGIA Goel, Anuj Gow, Alan J Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B Harris, Sarah E Hartman, Catharina A Havulinna, Aki S Hicks, Andrew A Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen, Rick Jarvelin, Marjo-Riitta Joehanes, Roby Johansson, Åsa Johnson, Andrew D Joshi, Peter K Jousilahti, Pekka Jukema, J Wouter Jula, Antti Kähönen, Mika Kathiresan, Sekar Keavney, Bernard D Khaw, Kay-Tee Knekt, Paul Knight, Joanne Kolcic, Ivana Kooner, Jaspal S Koskinen, Seppo Kristiansson, Kati Kutalik, Zoltan Laan, Maris Larson, Marty Launer, Lenore J Lehne, Benjamin Lehtimäki, Terho Liewald, David C M Lin, Li Lind, Lars Lindgren, Cecilia M Liu, YongMei Loos, Ruth J F Lopez, Lorna M Lu, Yingchang Lyytikäinen, Leo-Pekka Mahajan, Anubha Mamasoula, Chrysovalanto Marrugat, Jaume Marten, Jonathan Milaneschi, Yuri MORGAN, ANNA Morris, Andrew P Morrison, Alanna C Munson, Peter J Nalls, Mike A Nandakumar, Priyanka Nelson, Christopher P Niiranen, Teemu Nolte, Ilja M Nutile, Teresa Oldehinkel, Albertine J Oostra, Ben A O'Reilly, Paul F Org, Elin Padmanabhan, Sandosh Palmas, Walter Palotie, Aarno Pattie, Alison Penninx, Brenda W J H Perola, Markus Peters, Annette Polasek, Ozren Pramstaller, Peter P Nguyen, Quang Tri Raitakari, Olli T Ren, Meixia Rettig, Rainer Rice, Kenneth Ridker, Paul M Ried, Janina S Riese, Harriëtte Ripatti, Samuli ROBINO, ANTONIETTA Rose, Lynda M Rotter, Jerome I Rudan, Igor Ruggiero, Daniela Saba, Yasaman Sala, Cinzia F Salomaa, Veikko Samani, Nilesh J Sarin, Antti-Pekka Schmidt, Reinhold Schmidt, Helena Shrine, Nick Siscovick, David Smith, Albert V Snieder, Harold Sõber, Siim Sorice, Rossella Starr, John M Stott, David J Strachan, David P Strawbridge, Rona J Sundström, Johan Swertz, Morris A Taylor, Kent D Teumer, Alexander Tobin, Martin D Tomaszewski, Maciej Toniolo, Daniela TRAGLIA, MICHELA Trompet, Stella Tuomilehto, Jaakko Tzourio, Christophe Uitterlinden, André G Vaez, Ahmad van der Most, Peter J van Duijn, Cornelia M Vergnaud, Anne-Claire Verwoert, Germaine C Vitart, Veronique Völker, Uwe Vollenweider, Peter VUCKOVIC, DRAGANA Watkins, Hugh Wild, Sarah H Willemsen, Gonneke Wilson, James F Wright, Alan F Yao, Jie Zemunik, Tatijana Zhang, Weihua Attia, John R Butterworth, Adam S Chasman, Daniel I Conen, David Cucca, Francesco Danesh, John Hayward, Caroline Howson, Joanna M M Laakso, Markku Lakatta, Edward G Langenberg, Claudia Melander, Olle Mook-Kanamori, Dennis O Palmer, Colin N A Risch, Lorenz Scott, Robert A Scott, Rodney J Sever, Peter Spector, Tim D van der Harst, Pim Wareham, Nicholas J Zeggini, Eleftheria Levy, Daniel Munroe, Patricia B Newton-Cheh, Christopher Brown, Morris J Metspalu, Andres Hung, Adriana M O'Donnell, Christopher J Edwards, Todd L Psaty, Bruce M Tzoulaki, Ioanna Barnes, Michael R Wain, Louise V Elliott, Paul Caulfield, Mark J mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Stato di pubblicazione:	Pubblicato
Rivista:	NATURE GENETICS
Abstract:	High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Handle:	http://hdl.handle.net/11368/2929326
Digital Object Identifier (DOI):	http://dx.doi.org/10.1038/s41588-018-0205-x
URL:	https://www.nature.com/articles/s41588-018-0205-x
Appare nelle tipologie:	1.1 Articolo in Rivista

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